1
شیمی::
خاصیت فیزیکی-شیمیایی
Not all are going to become real drug candidates due to their inherent physicochemical properties.
A significant variation is seen in order to improve or eliminate drawbacks related to physicochemical properties which determine the pharmacokinetic behavior, and pharmaceutical and biological performance of already existing drugs.
Traditionally, the prodrug approach was aimed at improving the physicochemical properties of drugs via covalently attaching the drug moiety to a nontoxic chemical species, the promoiety.
The term "prodrug" or "proagent" was first introduced by Albert (1958) to signify pharmacologically inactive chemical derivatives that could be used to alter the physicochemical properties of drugs, in a temporary manner, to increase their usefulness and/or to decrease asso- ciated toxicity.
Awareness that the onset, intensity, and duration of drug action are greatly affected by the physicochemical properties of drugs has promoted the emergence of various theoretical and predictive models for drug design and evalua- tion.
واژگان شبکه مترجمین ایران